Nothing to Lose was met with negative reviews from professional critics. Review aggregator Rotten Tomatoes reports that 28% of the critics has given the film a positive review based on 25 reviews (7 "Fresh", 18 "Rotten") with an average rating of 5.1/10. Phil Villarreal of the Arizona Daily Star gave the film a positive review and stated, "Tim Robbins' understated depression and Martin Lawrence's hyperactive ranting are the perfectly hilarious foil for one another."
Audiences polled by CinemaScore gave the film an average grade of "A-" on an A+ to F scale.
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