Mannix is hired by attorney Noah Otway to find out why someone tried to kill Otway’s client, Dr. Graham Aspinall, a renowned surgeon whose specialty is removing tumors that are otherwise believed to be inoperable. Despite the doctor’s denials that anyone has a motive to kill him, Mannix comes to believe otherwise when he barely saves Aspinall from a second attempt on his life. And Mannix discovers that there are several people who might have a motive to kill Dr. Aspinall -- including the second-in-command at his medical institute; the boyfriend of one of Aspinall’s research assistants; and even his wife.