DeLuise's paid stage debut, at age 18, of Bernie the dog was in the drama Bernies Christmas Wish. His first steady gig was as an intern at the Cleveland Play House, 1952–54, as stage manager and actor.
In 1961, DeLuise played in the off-Broadway musical revue Another Evening with Harry Stoons, which lasted nine previews and one performance. Another member of the cast was 19-year-old Barbra Streisand. He was also in the off-Broadway play All in Love, which opened on November 10, 1961, at the Martinique Theatre and ran for 141 performances. Other New York theater performances included Half-Past Wednesday (off-Broadway) (1962); Around the World in 80 Days (off-Broadway) (1963); The Student Gypsy (Broadway) (1963); Here's Love (Broadway) (1963); and Last of the Red Hot Lovers (Broadway) (1969).
DeLuise generally appeared in comedic parts, although an early appearance in the movie Fail-Safe as a nervous USAF technical sergeant showed a broader range. His first acting credit was as a regular performer in the television show The Entertainers in 1964. He gained early notice for his supporting turn in the Doris Day film The Glass Bottom Boat (1966). In his review in The New York Times, Vincent Canby panned the film but singled out the actor, stating, "[T]he best of the lot, however, is a newcomer, Dom DeLuise, as a portly, bird-brained spy."
In the 1970s and 1980s, he often co-starred with his real-life friend Burt Reynolds. Together they appeared in the films The Cannonball Run and Cannonball Run II, Smokey and the Bandit II, The End, and The Best Little Whorehouse in Texas. DeLuise was the host of the television show Candid Camera from 1991 to 1992. He was a mainstay of Burke's Law, an American television series that aired on CBS during the 1993–1994 and 1994–1995 television seasons.
DeLuise also lent his distinctive voice to various animated films and was a particular staple of Don Bluth's features, playing major roles in The Secret of NIMH, An American Tail, A Troll in Central Park and All Dogs Go to Heaven (also with Reynolds). All Dogs Go to Heaven also featured Reynolds' voice as Charlie B. Barkin while DeLuise voiced Itchy Itchiford, Charlie's best friend, wing-man and later partner in business. Unlike DeLuise, however, Reynolds would not contribute a voiceover to any of the eventual film or television series or sequels.
DeLuise also voiced the incarnation of Charles Dickens' Fagin in the Walt Disney film Oliver & Company and made voice guest appearances on several animated TV series.
TV producer Greg Garrison hired DeLuise to appear as a specialty act on The Dean Martin Show. DeLuise ran through his "Dominick the Great" routine, a riotous example of a magic act gone wrong, with host Martin as a bemused volunteer from the audience. Dom's catchphrase, with an Italian accent, was "No Applause Please, Save-a to the End". The show went so well that DeLuise was soon a regular on Martin's program, participating in both songs and sketches.
Garrison also featured DeLuise in his own hour-long comedy specials for ABC. (Martin was often off-camera when these were taped, and his distinctive laugh can be heard.)
In 1968, DeLuise hosted his own hour-long comedy variety series for CBS, The Dom DeLuise Show. Taped in Miami at The Jackie Gleason Theater, it featured many regular Gleason show cast members including The June Taylor Dancers and The Sammy Spear Orchestra. DeLuise's wife Carol Arthur also regularly appeared. The 16-week run was the summer replacement for The Jonathan Winters Show. He later starred in his own sitcom, Lotsa Luck (1973–1974).
DeLuise was probably best known as a regular in Mel Brooks's films. He appeared in The Twelve Chairs, Blazing Saddles, Silent Movie, History of the World, Part I, Spaceballs, and Robin Hood: Men in Tights. Brooks' wife, actress Anne Bancroft, directed Dom in Fatso (1980).
DeLuise exhibited his comedic talents while playing the speaking part of the jailer Frosch in the comedic operetta Die Fledermaus at the Metropolitan Opera, playing the role in four separate revivals of the work at the Met between December 1989 and January 1996. In the production, while the singing was in German, the spoken parts were in English. A lifelong opera fan, he also portrayed the role of L'Opinion Publique in drag for the Los Angeles Opera's production of Offenbach's Orpheus in the Underworld.
An avid cook and author of several books on cooking, he appeared as a regular contributor to a syndicated home improvement radio show, On The House with The Carey Brothers, giving listeners tips on culinary topics. He was also a friend and self-proclaimed "look-alike" of famous Cajun chef Paul Prudhomme and author of seven children's books.
DeLuise also voiced the incarnation of Charles Dickens' Fagin in the Walt Disney film "Oliver & Company" and made guest appearances on several animated TV series.
