In 1997, at the age of seven, she sang "Up, over, through and under" (Sottosopra) at the Italian song contest Zecchino d'Oro. The song won the Zecchino d'Argento prize for the best non-Italian song.
She then starred in My Soul to Take, directed by Wes Craven. Co-stars included Max Thieriot and Nick Lashaway. She starred in the 2010 release, Twelve as a teenage drug addict. Meade appeared in the independent drama, Bluebird, in 2013. She had a supporting role in the first season of the HBO drama, The Leftovers. In 2016, she portrayed Sydney in the film Nerve starring Dave Franco and Emma Roberts. She received considerable critical acclaim for her portrayal of sex worker and porn star Lori Madison in HBO's The Deuce, creator David Simon describing her performance as "one of the best I ever got on a show".
After the 2017 Weinstein scandal and the Me Too movement highlighted the often routine nature of sexual harassment and misconduct in the industry, Meade was one of the first performers to demand professional safeguards for their well-being on set, leading to the presence of an intimacy coordinator on film and television series.
