Clayton was born in Dearborn, Michigan. He has Lebanese heritage. He began acting at Crestwood High School in Dearborn Heights, Michigan, performing in many of the drama club's productions. He later attended Oakland University, where he studied musical theater.
In 2010, he made appearances on Days of Our Lives and Shake It Up. In December 2012, he appeared in the Lifetime movie Holiday Spin, co-starring Ralph Macchio, as Blake, a rebellious teen forced to live with his father after his mother is killed in a car accident.
He was cast in 2013 in the role of Tanner in Disney's musical Teen Beach Movie, playing a cool but vacuous surfer who is "a mix between Frankie Avalon and Link from Hairspray". The film was directed by Jeffrey Hornaday and was filmed in Puerto Rico and was first broadcast in July 2013. It co-stars Ross Lynch, Maia Mitchell, and Grace Phipps.
He had a recurring role in the latter half of the first season of The Fosters. In 2016, he portrayed gay porn star Brent Corrigan in the film King Cobra, with James Franco and Christian Slater, and played the role of Link Larkin in the NBC television broadcast of Hairspray Live! He starred as Brady Mannion in the horror-thriller film Don't Hang Up, which was released in theaters in February 2017. Also in 2017, Clayton appeared on stage at the Pasadena Playhouse as Luke alongside Al Pacino and Judith Light in a six-week run of Dotson Rader's play God Looked Away, about the later life of Tennessee Williams.