In 1987, at age 15, Kimura auditioned to enter Johnny & Associates, a talent agency that recruits and trains young boys to become singers and members of boy bands. In Autumn 1987, twenty young boys, including Kimura, were put together into a group called The Skate Boys, which was initially created as backup dancers for a famous boy band, Hikaru Genji. In April 1988, producer Johnny Kitagawa chose six out of the twenty boys to create a new boy band; "SMAP."
In 2020, Kimura released his first solo album, entitled "Go with the Flow". The album, which included songs written for Kimura by well-known bands and artists such as [[Alexandros (band)|[ALEXANDROS]]], Superfly, Noriyuki Makihara, and Love Psychedelico, debuted at #1 on the Oricon Albums Chart on the week of its release. A month later, he held a four-day tour in both Tokyo and Osaka entitled "TAKUYA KIMURA Live Tour 2020 Go with the Flow". The concert was released on Blu-Ray and DVD, on July 8, 2020, debuting at #1 as well on the Oricon Charts.
On May 20, 2021, the Weibo Starlight Awards 2020 ceremony was held online. Kimura, alongside his two daughters, Cocomi and Kōki, were awarded alongside Western artists such as Katy Perry, Taylor Swift, and Louis Koo.
A follow up to his solo album "Go with the Flow" was released on January 19, 2022, entitled "Next Destination". The album features the song entitled "Mojo Drive", a collaboration between Kimura and renowned city-pop artist Tatsuro Yamashita, who wanted to write a song to highlight Kimura's baritone voice after attending his solo concert in February. Yamashita also composed two other tracks, namely "Good Luck, Good Time", and "Morning Dew" for the album. In addition to Yamashita, "Next Destination" also features songs written by Kyōka Suzuki, Sanma Akashiya, Man with a Mission, and Shigesato Itoi.