Bruni Tedeschi's debut film as a director, It's Easier for a Camel..., earned her two awards at the Tribeca Film Festival for Emerging Narrative Filmmaker and Best Actress in 2003. The film also won an award at the Ankara Flying Broom Women's Film Festival in 2004. It was also awarded Louis Delluc Prize for Best First Film. It was also entered into the 25th Moscow International Film Festival. According to Tim Palmer the film is an engaging example of contemporary French pop-art cinema, referring to directors who wittily merge the features of intellectual/arthouse cinema with mass/popular cinema, putting Bruni Tedeschi in the company of other filmmakers such as François Ozon, Maîwenn le Besco, Sophie Fillières, Serge Bozon, etc.
At the 2005 Berlinale, the Berlin International Film Festival, Bruni Tedeschi appeared to promote two films she had acted in: Tickets (2005), a three-segment film directed by Ermanno Olmi, Abbas Kiarostami, and Ken Loach, and Crustacés et Coquillages, a comedy directed by the French duo of Olivier Ducastel and Jacques Martineau.
In 2007, Bruni Tedeschi directed Actrices, which won the Prix Spécial du Jury at the 2007 Cannes Film Festival. Her 2022 film Les Amandiers (Forever Young) also premiered in the main competition of the 2022 Cannes Film Festival.
